Use this guide to prepare manuscripts that meet the journal's clinical and ethical standards.

Include complete author information, affiliations, ORCID identifiers, funding disclosures, and contribution statements on the title page.

Provide structured abstracts, clear study design, and complete statistical reporting to support reproducibility.

Clinical trials must include registry details; observational studies should align with STROBE and appropriate reporting frameworks.

Ensure all figures, tables, and supplementary files are referenced in order and properly labeled.

Include a short running title and corresponding author contact details on the title page.

Ensure tables are editable and cited in the text in sequential order.

Describe data preprocessing steps and provide analysis code where feasible.

Include acknowledgments for medical writing or statistical support.

Use a structured abstract with objectives, methods, results, and conclusion.

Include trial registration details in the abstract and methods section when applicable.

Provide complete author affiliations and corresponding author contact details.

List funding sources and sponsor roles clearly on the title page.

Disclose conflicts of interest, including pharmaceutical relationships.

Describe patient selection criteria and exclusion details in the methods.

Specify primary endpoints and secondary outcomes with definitions.

Include statistical methods, software versions, and handling of missing data.

Provide power calculations or justification for sample size when required.

Use SI units and define abbreviations at first use.

Figures should be high resolution and de-identified with clear legends.

Tables must be editable and include units and abbreviations in footnotes.

Supplementary files should be labeled and cited in the main text.

Describe data preprocessing and analytic pipelines for reproducibility.

Use reporting guidelines appropriate to study design, including REMARK for prognostic studies.

Include a limitations section addressing bias and generalizability.

Ensure references are in Vancouver style with DOIs where available.

Provide ethics committee approvals and consent documentation.

Include a data availability statement with repository links or access terms.

Describe patient privacy protections for sensitive data.

Submit a cover letter summarizing novelty and clinical relevance.

Confirm all coauthors have approved the final submission.

Ensure figures and tables are cited in sequential order.

Use continuous line numbering to support reviewer comments.

Include a running title and keywords aligned with MeSH terms.

Check consistency between abstract results and main text findings.

Provide clear descriptions of interventions and comparators.

State whether protocols were registered and provide identifiers.

Clarify deviations from registered protocols when applicable.

Include acknowledgments for medical writing or statistical assistance.

Confirm that patient images have explicit consent for publication.

Use plain language summaries when appropriate for clinical translation.

Ensure all supplementary datasets include documentation and codebooks.

Provide data citations for external repositories and accession numbers.

Report adverse events and safety monitoring for interventional studies.

Use consistent terminology for leukemia subtypes and classification systems.

Include manuscript word count and figure/table counts on the title page.

Describe clinical setting and care context for cohort studies.

Provide registry identifiers for clinical trial submissions.

Ensure tables and figures align with narrative interpretations.

Verify author order and contributions before final submission.

Confirm compliance with journal ethics and transparency policies.

Ensure all datasets and supplementary materials have consistent naming conventions.

Include clinical trial protocols or registration summaries when requested by reviewers.

Provide clear figure legends that can stand alone without the main text.

State whether any AI tools were used for language support and disclose appropriately.

Ensure all patient identifiers are removed from images and datasets.

Describe consent procedures for case reports and clinical images.

Provide study timelines and follow-up periods for longitudinal analyses.

Include rationale for subgroup analyses and multiplicity adjustments.

Ensure statistical assumptions are stated and validated where necessary.

Report confidence intervals alongside key effect estimates.

Describe inclusion of control cohorts or comparator arms clearly.

Use consistent terminology for leukemia subtypes across all sections.

Include details on laboratory assays and thresholds for biomarker studies.

Document software and pipelines for genomic or bioinformatics analyses.

Ensure references are checked for accuracy and completeness before submission.

Provide a summary of clinical relevance in the discussion section.

Include acknowledgments for contributing institutions or collaborative groups.

Ensure supplementary figures meet resolution and labeling standards.

Confirm that all authors approve the final proofs before publication.

Provide study registration details for clinical trials and observational cohorts.

Describe randomization, blinding, and allocation concealment when applicable.

Include flow diagrams for clinical trial and systematic review submissions.

Report adverse events and safety outcomes with clear definitions.

Ensure statistical results include effect sizes and confidence intervals.

Explain handling of outliers and missing values in the analysis.

Provide version numbers for genomic pipelines and analysis software.

Include supplementary protocols and analysis plans when required.

State data access restrictions and how requests are evaluated.

Use consistent figure labeling and color schemes across panels.

Provide IRB approval numbers and consent details in the methods.

Include a brief description of clinical significance in the discussion.

Ensure all clinical abbreviations are defined at first use.

Confirm references are complete and formatted consistently.

Include correspondence details and author contributions on the title page.

For case reports, include patient consent and anonymization details.

For translational studies, describe specimen handling and storage.

Use standardized disease classification systems where applicable.

Ensure the abstract matches the final results presented in the text.

Include a concise statement of study objectives and hypotheses.

Provide clear definitions for primary and secondary outcomes.

Summarize patient demographics and baseline characteristics.

Describe inclusion of control groups and comparator treatments.

State the statistical threshold for significance and adjustments used.

Provide protocols for laboratory assays and validation steps.

Ensure figures are labeled consistently with the text discussion.

Include any relevant registry or protocol identifiers prominently.

Describe quality control procedures for data and sample handling.

Add a brief statement on clinical implications and future directions.

Check that all supplementary material is referenced in the main text.

Provide a brief summary of limitations and potential biases.

Clarify whether data were collected prospectively or retrospectively.

Include a list of abbreviations if extensive terminology is used.

Ensure ethical approvals align with study sites and jurisdictions.

Provide a concise statement of novelty in the cover letter.

Confirm that all supplementary data have corresponding captions.

Ensure consistent terminology in tables, figures, and narrative text.

Describe follow-up periods and censoring rules for survival analyses.

Provide clear definitions for response criteria and endpoints.

Ensure all tables include units and abbreviations in footnotes.

Confirm that supplementary files are uploaded in the correct formats.

Include a brief statement on clinical relevance in the discussion.

Disclose conflicts of interest and funding sources, including pharmaceutical relationships when applicable.

Include data availability statements with repository links, controlled access terms, or justified restrictions.

Use CONSORT, STROBE, PRISMA, CARE, ARRIVE, or REMARK guidelines when applicable and upload checklists.

Describe statistical methods, missing data handling, and sensitivity analyses to support clinical decisions.