Dr. Cristiano Spadaccio

Address:

Department of Cardiac Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

Academic Metrics

• h-index: 44
• i10-index: 132
• Total Citations: 5895

Research Interests:

• Cardiothoracic Surgery and Innovation
• Tissue Engineering and Biomaterials
• Proteomic Analysis and Oxidative Stress
• Aortic Valve Replacement (SuAVR, TAVR)
• Minimally Invasive Cardiac Surgery
• Aortic Aneurysm Pathogenesis

Biography:

Dr. Cristiano Spadaccio is a Clinical Fellow and researcher specializing in Cardiothoracic Surgery and the analysis of biomaterials and proteomics in cardiovascular disease. His primary research is focused on aortic valve replacement, advancing techniques such as sutureless devices and minimally invasive surgery. He is a recognized expert in tissue engineering, particularly for developing innovative, self-regenerating heart valves. His work spans clinical surgery, basic science on oxidative stress, and the molecular mechanisms underlying aneurysm pathology.

Education Details

• Ph.D. (Biomedical Sciences), Sapienza University of Rome, Italy (2010)
• M.D. (Medicine and Surgery), University Campus Bio-Medico of Rome, Italy (2006)
• Residency (Cardiothoracic Surgery), University Campus Bio-Medico of Rome, Italy (2012)
• Focused Clinical Fellowship (Cardiac Surgery), Harvard Medical School - Massachusetts General Hospital, USA (2022)

Professional Background

• Clinical Fellow/Researcher (Current), Department of Cardiac Surgery, University of Cincinnati College of Medicine, USA.
• Faculty Member/Clinical Fellow, Campus Bio-Medico University, Rome, Italy.
• Postdoctoral Research Fellowship, University of Pittsburgh Medical Center, USA (2008).
• Clinical/Research Fellow in Cardiothoracic Surgery at various international centers, including the West of Scotland Heart and Lung Centre, UK.

Achievements

• Significant contributions to the field of cardiac tissue engineering, including work on electrospun nanocomposites and heart valve scaffolds.

Current Research Projects

Dr. Spadaccio's research focuses on innovation in cardiac surgery and cardiovascular biology:

• CorTricuspid ECM Valve: Development and clinical evaluation of the first totally tissue-engineered valve for tricuspid replacement.
• Sutureless and Minimally Invasive Techniques: Meta-analyses and clinical studies on the long-term outcomes of sutureless and transcatheter aortic valve replacement (SuAVR-TAVR trials).
• Proteomic Biomarkers: Redox proteomic analysis of serum proteins involved in the pathogenesis of Aortic Aneurysms (AAA).

Academic Profiles of Dr. Cristiano Spadaccio

Explore his academic and professional presence across trusted platforms.

• ​ResearchGate
• Google Scholar
• University Profile

Publications:

Dr. Spadaccio maintains a prolific publication record focusing on the translational research of advanced nanomaterials for environmental and engineering applications.

• Spadaccio, C., Panza, A., Vester, R., Morales, D., & Louis, L. (2025). Advances in Tissue Engineering of the Heart Valves: The CorTricuspid ECM Valve. CTSNet. DOI: 10.25373/ctsnet.28946225.
• Spadaccio, C. (2025). A case for sutureless valve devices in the arena of aortic valve replacement. Open Access Journals. DOI: 10.37532/1755- 5310.2025.17(1).970.
• Spadaccio, C., Dimagli, A., Agler, C. J., & Rose, D. (2025). Exploring Use-Rates of and Scientific Evidence on Sutureless Devices in Aortic Valve Replacement: A Bibliographic Meta-Analysis and Clinical Considerations. Journal of Functional Morphology and Integrated Medicine.
• Spadaccio, C., Hinna Danesi, T., Glenn, C. J., Panza, A., Balkhy, H., & Rose, D. (2025). How We Perform Right Anterior Minimally Invasive Approach for Aortic Valve Replacement. The Heart Surgery Forum, 28(7), E515-E526. DOI: 10.59958/hsf.8423.
• Nappi, F., Schoell, T., Singh Avtaar Singh, S., & Spadaccio, C. (2025). Measuring Stress on a Third-Generation Balloon-Expandable Aortic Valve During Expansion. Article.

 

Last Updated on October 03, 2025