Recently Published Articles
Ordeals of Sexually Violated Women and Access to Comprehensive Healthcare: A Case Study of Victims of Sexual Violence in North Kivu, Eastern Congo
Abstract:
The impact of sexual violence in any community is extremely devastating and women in the Eastern part of the Congo are no exception. Sexual violence not only affects the health of women, but it impacts their social life within the community too. The study aims to investigate the experiences of female victims of sexual violence in accessing medical care in North Kivu. An interpretive, phenomenological approach was used for this inductive and qualitative study. In-depth informant interviews were the main data collection tool. Open-ended questions were used during the interviews in order to garner more information from the interviewees. Heidegger’s approach was utilized in analyzing the collected ...
Endocrine Disrupting Chemicals: Epigenetic Relevance and Mechanisms
Abstract:
Genetics alone cannot thoroughly expound the environmental impact on the molecular complexity of the endocrine system. Epigenetic-induced alteration in gene expression has emerged as a way in which environmental compounds may exert endocrine effects. The environmental compounds that interfere with normal endocrine signaling are one of the largest classes of toxicants we are exposed to, on a daily basis. Epigenetic mechanisms, mainly the methylation of DNA and the modification of histones, lead to differentiated activation and deactivation of genome domains creating phenotype plasticity and divergent endocrine function among populations and individuals, as well. The issues examined in the present review are related to environmental epigenetics, and more precisely, the epigenetic-mediated modulation and relevance of endocrine disrupting chemicals, focusing on three broad aspects: 1) persistence of EDs, 2) their major hormonal effects and 3) the potential of compou...
Appropriate Conservation Machinery for Mungbean Cultivation in the Southern Region of Bangladesh
Abstract:
The study was conducted at Mundopasha, Wazirpur, Barisal during Rabi season of 2017 for testing, adoption and popularization of different conservation machinery (CA) such as zero till planter (ZT), strip till planter (ST), bed planter (BP) and power tiller operated seeder (PTOS) along with conventional tilling and of sowing method for planting of mungbean (BARI Mung-6). The soil type was loamy-sand with bulk density 1.41 g/cc. The effective field capacities of ZT, ST, BP, PTOS and power tiller were found to be 0.104, 0.109, 0.084, 0.109, and 0.074 ha/h, respectively. The field efficiency of ZT, ST, BP, PTOS and power tiller were estimated as 74.68, 76.47, 75.84, 78.16 and 71.52%, respectively. Significantly the highest mungbean grain yields were found from ZT and ST planted plots than those of other plots. Significantly the lowest grain yield was obtained from conventional tillage and broadcasting method. The highest benefit cost ratio (BCR) was obtained from ST p...
Morpho-biochemical Identification and Antimicrobial Susceptibility Testing of Bacterial Isolates from Chicken Eggs in District Faisalabad
Abstract:
Microorganisms are the main cause of food-borne illness in humans that may occur by consuming unhygienic products from poultry and other sources. With the passage of time bacterial resistance to antibiotics is ever-increasing which necessitates development of new antibiotics. One of the most obvious reasons of antimicrobial resistance in human-beings is the consumption of contaminated food with microbes. The aim of present study is to isolate, identify and characterize the food-borne pathogens from chicken eggs. For this purpose, a total of 240 egg samples were collected from eight different towns of Faisalabad. Samples were collected from egg surface, yolk, albumin and egg tray. Isolation, identification and characterization of commonly occurring egg borne pathogens including
Sulfonamides: Historical Discovery Development (Structure-Activity Relationship Notes)
Abstract:
Sulfonamide group is a magic group introduced as the main core for different bio-activities in drug industry. According to its substitutes, literature divides sulfonamide derivatives to antibacterial sulfonamides and non-anti-bacterial sulfonamides. As Data was collected from different sources such as Drug Bank.com and Pubchem.com databases and then was analyzed, we found that these compounds are different in their pharmacokinetics and pharmacodynamics; in addition to their sulfa cross allergy property. We presented these differences from these compounds changes in their chemical structure, in a way to build a solid base that can be depended on for developing new drugs from these compounds that interact with different receptors.
Chitin and Chitinases: Biomedical And Environmental Applications of Chitin and its Derivatives
Abstract:
Disposal of chitin wastes from crustacean shell can cause environmental and health hazards. Chitin is a well known abundant natural polymer extracted after deproteinization and demineralization of the shell wastes of shrimp, crab, lobster, and krill. Extraction of chitin and its derivatives from waste material is one of the alternative ways to turn the waste into useful products. Chitinases are enzymes that degrade chitin. Chitinases contribute to the generation of carbon and nitrogen in the ecosystem. Chitin and chitinolytic enzymes are gaining importance for their biotechnological applications. The presence of surface charge and multiple functional groups make chitin as a beneficial natural polymer. Due to the reactive functional groups chitin can be used for the preparation of a spectrum of chitin derivatives such as chitosan, alkyl chitin, sulfated chitin, dibutyryl chitin and carboxymethyl chitin for specific applications in different areas. The present rev...
Physico-Chemical and Bacteriological Quality of Water from Boreholes in Otuoke Community, Bayelsa State, Nigeria
Abstract:
The concern over exposure to drinking water contaminated and the resultant adverse effect on human health has prompted several studies evaluating the quality of drinking water sources. This study was carried out to determine the bacteriological and Physico-chemical qualities of commercial borehole water within Otuoke community in Bayelsa state Nigeria. Ten (10) water samples were collected from the various locations designated as (A-J). The Physico-chemical parameters were determined by using the photometric technique through the Colour Q photometer and the bacteriological analysis was determined by using aerobic plate method. The Physico-chemical parameters of the water samples analysed were within the acceptable limit of WHO standard of drinking water quality except for Bromine and cyanuric acid which ranged from 1.6±0.1 to 2.7±0.1 and 2±1 to 9±1 respectively. The Result of total bacteria count obtained from the borehole water samples ranged from 1.1 x 10
Hydrolysis of Cellulose by Soluble Clostridium Thermocellum and Acidothermus Cellulolyticus Cellulases
Abstract:
The goal of this work was to clone, express, characterize and assemble a set of soluble thermostablecellulases capable of significantly degrading cellulose. We successfully cloned, expressed, and purified eleven
The Effect of Laser Irradiation on Reparative Osteogenesis
Abstract:
The use of non-medicinal facilities for correcting processes in various pathological conditions is one of the most urgent problems of modern medicine. To study the effect of low-intensity infrared laser radiation on reparative bone formation and angiogenesis in bone regeneration which is formed in treatment of fractures under conditions of transosseous osteosynthesis. A tibia fracture was modeled experimentally in rats in the control and experimental groups. Reposition and fixation of fragments were performed. The fracture zone in the experimental group animals was exposed to the impact of pulsed infrared laser irradiation of low intensity. Animals from the control gr...
Current Status and Future Perspectives of Gene Therapy for Heart Failure
Abstract:
Heart failure(HF) is a disease with high morbility and mortality. The benefits of current pharmacological and device therapy for survival outcomes of patients with HF are limited. Gene therapy represents a novel promising strategy in treating HF, as it can theoretically normalize the aberrantly expressed genes and their regulatory mechanisms permanently. However, the translation of gene therapy for HF from bench to bedside has been less successful. There are many challenges ahead for gene therapy, especially in the areas of selection of the optimal targets, the needs for developing delivery systems and the improvement in design of clinical trials. In this review, we summarize the most promising gene targets which have been used in experimental and clinical studies for treating HF, highlighting the results from several clinical trials. We also review the latest development in gene therapy vectors and delivery methods, aiming to provide directions for future studies...