Research Topic · Peer-Reviewed

Targeted Therapy

Targeted therapy is a class of cancer treatment directed at specific molecular alterations that drive tumor growth, survival, and dissemination, sparing normal cells more effectively than conventional cytotoxic chemotherapy. It includes small-molecule inhibitors of kinases and signaling enzymes, monoclonal antibodie…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 15× across the literature 🔖 ISSN 2574-4496 🗓 Reviewed July 2026

Overview

Targeted therapy is a class of cancer treatment directed at specific molecular alterations that drive tumor growth, survival, and dissemination, sparing normal cells more effectively than conventional cytotoxic chemotherapy. It includes small-molecule inhibitors of kinases and signaling enzymes, monoclonal antibodies against cell-surface receptors, and agents aimed at intracellular pathways, with selection increasingly guided by molecular diagnostics that identify actionable drivers such as oncogenic kinase fusions, receptor amplifications, and pathway-activating mutations. By interrupting defined biological dependencies, targeted agents can produce durable responses, though acquired resistance and bypass signaling remain central challenges, motivating combination strategies with chemotherapy, radiation, or immunotherapy. The peer-reviewed research in this area covers the molecular rationale and clinical application of targeted approaches, including molecular diagnosis in the management of Thyroid Cancer, pH-sensitive nanomedicine for gynecological cancers, immunotherapy use in pulmonary resection, microRNA expression as a biomarker correlating with PD-L1 status and survival in melanoma, and the evolution of myeloproliferative neoplasms relevant to tyrosine-kinase-directed treatment. Related work explores microRNAs as therapeutic tools in cardiovascular disease. Recurring themes include biomarker-driven patient selection, the integration of nanotechnology and molecular profiling into drug delivery, mechanisms of response and resistance, and the convergence of targeted, immunological, and conventional therapies within precision-oncology frameworks for diverse malignancies.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2020

pH-Sensitive Nanomedicine for Treating Gynaecological Cancers

Vishwanath Prasad PramodCorresponding author
Center for Biomedical Research, Population Council, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Exact topic Women's Reproductive Health Cited by 8 doi:10.14302/issn.2381-862X.jwrh-19-3143

How this research is being cited

The 12 articles above have been cited 15 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Targeted Therapy, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Thyroid Cancer (ISSN 2574-4496).

Journal editorial board
Giovanni Mauri · Italy Pamela Pinzani · Italy Byeong-Cheol Ahn · South Korea

This page summarises published research for orientation; it is not medical or professional advice.