Research Topic · Peer-Reviewed

Differentiated Thyroid Cancers

Differentiated thyroid cancers are malignancies that arise from the follicular epithelial cells of the thyroid gland and retain many features of normal thyroid tissue, including the capacity to take up iodine and respond to thyroid-stimulating hormone. They comprise predominantly papillary thyroid carcinoma and foll…

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 20× across the literature 🔖 ISSN 2574-4496 🗓 Reviewed July 2026

Overview

Differentiated thyroid cancers are malignancies that arise from the follicular epithelial cells of the thyroid gland and retain many features of normal thyroid tissue, including the capacity to take up iodine and respond to thyroid-stimulating hormone. They comprise predominantly papillary thyroid carcinoma and follicular thyroid carcinoma, together accounting for the large majority of thyroid cancers, and are generally associated with a favorable prognosis and high long-term survival. Diagnosis typically begins with neck ultrasound and fine-needle aspiration cytology, increasingly supported by molecular and microRNA markers that aid risk stratification and help distinguish well-differentiated tumors from more aggressive forms. As reflected in the listed research, microRNA profiling has been examined across the spectrum from differentiated to poorly differentiated and anaplastic carcinoma, illustrating how molecular signatures track loss of differentiation. Management is centered on surgery, most often thyroidectomy, and on the use of radioactive iodine ablation to eliminate residual or metastatic iodine-avid disease, complemented by thyroid-stimulating-hormone suppression to reduce recurrence. Treatment outcomes for well-differentiated disease are generally excellent, though extent of surgery and use of radioactive iodine are individualized according to risk. Differentiated thyroid cancers contrast sharply with poorly differentiated and anaplastic carcinomas, which lose differentiated features, lose iodine avidity, behave far more aggressively and carry a substantially worse prognosis.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2019

Image Guided Ablations for Thyroid Tumours

Nicosia LucaCorresponding author
Division of Breast Radiology, European Institute of Oncology IRCCS, Milan, Italy, European Institute of Oncology IEO, IRCCS, Via Giuseppe Ripamonti, 435 - 20141 Milano MI, Italy
Thyroid Cancer Cited by 2 doi:10.14302/issn.2574-4496.jtc-19-2657
2018

In The Pursuit of The Perfect Thyroid Care

Kumar Sahoo ManasCorresponding author
Consultant Nuclear Medicine & PET/CT, Department of Nuclear Medicine &PET-CT. Medanta-The Medicity, Gurugram, India.
Thyroid Cancer doi:10.14302/issn.2574-4496.jtc-18-1986

How this research is being cited

The 11 articles above have been cited 20 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Differentiated Thyroid Cancers, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Thyroid Cancer (ISSN 2574-4496).

Journal editorial board
Giovanni Mauri · Italy Pamela Pinzani · Italy Byeong-Cheol Ahn · South Korea

This page summarises published research for orientation; it is not medical or professional advice.