Use of a Novel Exogenous Allogeneic Multi-Growth Factor Concentrate in Bone Regeneration of the Mandible: A Case Report
Regeneration of new bone continues to be one of the most significant challenges in implant dentistry to correct osseous deficiencies in preparation for dental implant surgery. The need for effective bone regenerative strategies has fueled the development of many therapeutic methods, including the use of biologics such as bone morphogenetic proteins, bone marrow aspirates, mesenchymal stem cells, and platelet-derived growth factors. One therapeutic strategy that has not been investigated is the use of exogenous growth factors on bone regeneration of the jaws. The goal of this study is to evaluate if a novel exogenous allogeneic multi-growth factor concentrate, AlloSpark-GF has a positive effect on bone regeneration in the grafted mandible using histology and histomorphometry.