Research Topic · Peer-Reviewed

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is an aggressive malignancy of hematopoietic progenitor cells in which immature myeloid blasts proliferate clonally in the bone marrow and peripheral blood, impairing normal production of red cells, platelets, and functional leukocytes. The disease arises from acquired genetic and epigen…

Curated from this journal's research 📚 6 peer-reviewed articles cited Cited 7× across the literature 🔖 ISSN 2998-4785 🗓 Reviewed June 2026

Overview

Acute myeloid leukemia (AML) is an aggressive malignancy of hematopoietic progenitor cells in which immature myeloid blasts proliferate clonally in the bone marrow and peripheral blood, impairing normal production of red cells, platelets, and functional leukocytes. The disease arises from acquired genetic and epigenetic alterations affecting transcription factors, signaling kinases, and chromatin regulators that block myeloid differentiation and promote uncontrolled self-renewal. Clinically, marrow failure manifests as anemia, thrombocytopenia with bleeding, and neutropenia predisposing to infection, and leukemic infiltration can occasionally produce extramedullary or cutaneous lesions. Diagnosis integrates morphology, flow-cytometric immunophenotyping, cytogenetics, and molecular profiling, which together define disease subtypes and stratify prognosis. Recurrent abnormalities and biomarkers guide risk classification and increasingly inform targeted therapy, complementing conventional cytotoxic induction and consolidation chemotherapy. For eligible patients, allogeneic hematopoietic stem cell transplantation offers potential cure through graft-versus-leukemia immunity, though it carries risks including immune-mediated complications. Epigenetic dysregulation and metabolic dependencies are active areas of investigation, and emerging cellular and immunotherapeutic strategies aim to eliminate residual leukemic stem cells. AML is more common in older adults, often follows a rapid course, and demands prompt diagnosis and individualized treatment to optimize outcomes and manage relapse.

Research published in this journal

6 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Epigenetics and Nutrition

Lundstrom KennethCorresponding author
PanTherapeuitcs, Rue des Remparts 4, CH1095 Lutry, Switzerland
Exact topic International Journal of Nutrition Cited by 2 doi:10.14302/issn.2379-7835.ijn-14-603
2018

Molecular Biomarkers: A Brief Review

Tarassishin LeonidCorresponding author
 Department of Biological Sciences.
Exact topic Proteomics and Genomics Research doi:10.14302/issn.2326-0793.jpgr-18-2418

How this research is being cited

The 6 articles above have been cited 7 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Acute Myeloid Leukemia, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Neonatology (ISSN 2998-4785).

Journal editorial board
Giovanna Bertini · Italy Carmine Garzillo · Italy Rasheda Khanam · United States

This page summarises published research for orientation; it is not medical or professional advice.