Research Topic · Peer-Reviewed

Inflammation

Inflammation is the coordinated biological response of vascularised tissue to harmful stimuli such as infection, injury, irritants, or autoimmune activation, serving to eliminate the inciting agent, clear damaged cells, and initiate repair. The classical signs of heat, redness, swelling, pain, and loss of function a…

Curated from this journal's research 📚 7 peer-reviewed articles cited Cited 32× across the literature 🗓 Reviewed June 2026

Overview

Inflammation is the coordinated biological response of vascularised tissue to harmful stimuli such as infection, injury, irritants, or autoimmune activation, serving to eliminate the inciting agent, clear damaged cells, and initiate repair. The classical signs of heat, redness, swelling, pain, and loss of function arise from vascular and cellular events, including increased blood flow, heightened vascular permeability, and the recruitment of leukocytes guided by chemical mediators such as cytokines, chemokines, and eicosanoids. Acute inflammation is typically self-limiting and protective, whereas persistent or dysregulated responses produce chronic inflammation that contributes to tissue damage and underlies many disorders, including autoimmune diseases, arthritis, metabolic and respiratory conditions, and inflammatory changes in epithelial and ocular tissue. At the molecular level, signalling pathways governed by transcription factors such as NF-κB regulate the expression of inflammatory genes, and their modulation is central to controlling the intensity and resolution of the response. Research in this field examines how genetic and environmental factors shape susceptibility, how inflammation interacts with infection and injury across organ systems, and how dietary, pharmacological, and natural compounds may attenuate inflammatory signalling. Understanding the mechanisms that initiate, amplify, and resolve inflammation is fundamental to developing anti-inflammatory strategies and to clarifying the role of immune-mediated injury in acute and chronic disease.

Research published in this journal

7 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 7 articles above have been cited 32 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Inflammation, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Inflammation Research.

Journal editorial board
Thomas Boldicke · Germany Graziella Curtale · Italy Frederic Velard · France

This page summarises published research for orientation; it is not medical or professional advice.