Research Topic · Peer-Reviewed

Apoptosis

Apoptosis is a genetically programmed form of cell death by which cells dismantle themselves in a controlled manner, preserving membrane integrity and avoiding the inflammation associated with necrosis. It is executed through two principal routes that converge on caspase activation: the intrinsic (mitochondrial) pat…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 85× across the literature 🗓 Reviewed June 2026

Overview

Apoptosis is a genetically programmed form of cell death by which cells dismantle themselves in a controlled manner, preserving membrane integrity and avoiding the inflammation associated with necrosis. It is executed through two principal routes that converge on caspase activation: the intrinsic (mitochondrial) pathway, governed by the balance of pro- and anti-apoptotic BCL-2 family members such as BCL-2, BAK, and BAX that control mitochondrial outer-membrane permeabilization and cytochrome c release, and the extrinsic pathway, triggered by death-receptor ligation. Morphologically the process is marked by chromatin condensation, DNA fragmentation, cytoplasmic shrinkage, and the formation of apoptotic bodies cleared by phagocytes. Apoptosis is essential to development, tissue homeostasis, and the elimination of damaged or potentially malignant cells, so its dysregulation contributes to cancer, degenerative disease, and impaired responses to therapy. Research in this area examines apoptosis in stored platelets, oxidative stress- and lipopolysaccharide-induced testicular cell death, resistance to butyrate-induced apoptosis in colorectal cancer, the role of BCL-2 and BAK in kidney disease, and the apoptotic and cytotoxic activity of agents such as silver nanoparticles against tumour cell lines. The journal publishes peer-reviewed research on programmed cell death, its molecular regulation, and its role in disease and therapeutic response.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 85 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Apoptosis, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Advanced Cytology.

Journal editorial board
Krzysztof Marycz · Poland MARIA VIOLETTA BRUNDO · Italy

This page summarises published research for orientation; it is not medical or professional advice.